Video on HIVToolbox. The goal of this project is to create an integrated webtool that can be used to investigate potential drug targets in HIV. HIVtoolbox is an analytic tool that integrates data for all HIV proteins. The application has a sequence window that maps domains, functional sites, protein-protein interactions, and potential functional minimotifs to the sequence (Sargeant et al, 2008). The sequence is interactively coupled to three structure viewers that are synchronized. These structure windows shows structures colored by domains, predicted minimotifs, functional sites, protein-protein interactions, and sequence conservation. Sequence conservation is calculated for many thousand different sequences from isolates. This is integrated with a species/group/clade selected and sequence alignment/PSSM display. HIVtoolbox was built by David Sargeant, Sandeep Deverasetty, and previous lab member Angel Villahoz Baleta. See Wikipedia article. Also see the presentation at the 2012 IAS meeting IAS meeting presentation.

PLEASE CITE USE OF HIVTOOLBOX WITH THIS PAPER:
Sargeant D, Deverasetty S, Luo Y, Baleta AV, Zobrist S, Rathnayake V, Russo JC, Vyas J, Muesing MA, and Schiller MR (2011) HIVToolbox, an integrated web application for investigating HIV. PLoS One, 6, e20122. PMID: 21647445